Serum branched-chain amino acids modifies the associations between air pollutants and insulin resistance

Growing evidence supports that air pollution exposure has become a risk factor of type II diabetes mellitus through the induction insulin resistance (IR), but presented findings did not provide consistent relationship between and IR in temporal scale magnitude. Reported associated with exposure, branched-chain amino acids (BCAAs) blood might modify association IR. We took advantage an existing panel study on elderly people who were healthy or pre-diabetes. Amino analyzed from serum samples using UPLC-QQQ-MS, homeostasis model assessment (HOMA-IR) values calculated to represent levels each visit. Exposures PM2.5, NO2, SO2, CO, O3, black carbon (BC) estimated data monitoring station. Linear mixed-effects models applied estimate associations HOMA-IR, as well modifying effects BCAAs. found significantly higher concentrations BCAAs pre-diabetic subjects than ones. The all HOMA-IR. For high-level BCAAs, HOMA-IR was positively IQR increase BC, CO at lag day 2 7. While for low-level there no significant observed any except 5. provided circulating may level humans.